Sara Hägglund

Jag är veterinär och forskare med inriktning idisslares infektiösa sjukdomar och immunitet. I mitt arbete ingår klinisk och teoretisk undervisning, ffa rörande digestionssjukdomar hos nötkreatur.  Jag arbetar även på Idisslarkliniken och har uppdrag som kursledare för Produktionsdjur inklusive livsmedelssäkerhet Åk 5, samt som delkursledare för Idisslarmedicin inom Klinisk veterinärmedicin Åk 4-5.

Min forskning fokuserar på inflammation och virusorsakade sjukdomar. Jag arbetar i nötkreatursbesättningar samt på laboratorie, med kartläggning av virus epidemiologi och smittspridning, immunologi, sjukdomsmekanismer, persistens samt utveckling och utvärdering av vacciner och laboratorietester. Det övergripande målet är att utveckla effektiva kontrollmetoder, såsom vacciner, nya behandlingsmetoder och smittskydd baserat på evidens.

I forskarrollen ingår även handledning av forskarstuderande samt projektledning.  Aktuella projekt handlar om bakteriell och viral lunginflammation, bovint respiratoriskt syncytialt virus, influenzavirus typ D och mul-och-klövsjukevirus.

Bovine Respiratory Syncytial Virus (BRSV) - Tracing sources and transmission pathways between herds to design adapted biosecurity measures for the development of a sustainable BRSV control program. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2017-01-01 to 2020-12-31 Grant number: 2016-00463 https://app.dimensions.ai/details/grant/grant.8444911 (co-PI)

New treatment approaches for bovine respiratory disease. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2016-01-01 to 2021-12-31. Grant number: 2016-01770 https://app.dimensions.ai/details/grant/grant.8443817 (PI)

Strengthening Animal Production and Health through the Immune Response  European Commission (Brussels) 2015-03-01 to 2019-03-01 Grant number: 633184 https://grants.uberresearch.com/501100000780/193183/Strengthening-Animal-Production-and-Health-through-the-Immune-Response (co-PI)

Host response gene signatures associated with FMDV infection, vaccination and persistence. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2014-11-01 to 2016-12-31 Grant number: 2014-01844  https://app.dimensions.ai/details/grant/grant.8444391 (I)

Bluetongue and Immunostimulating Complexes (BT-ISCOMs): Development and evaluation of a DIVA subunit vaccine. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm) 2010-01-01 to 2012-12-31 Grant number: 2009-1593  https://grants.uberresearch.com/501100001862/19723/Bluetongue-and-Immunostimulating-Complexes-BT-ISCOMs-Development-and-evaluation-of-a-DIVA-subunit-vaccine (co-PI)

Development and comparative evaluation of three new generation BRSV DIVA vaccines and a corresponding DIVA test. Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (Stockholm)2009-01-01 to 2009-12-31 Grant number: 2010-2158 https://grants.uberresearch.com/501100001862/25205/Development-and-comparative-evaluation-of-three-new-generation-BRSV-DIVA-vaccines-and-a-corresponding-DIVA-test (PI, coordinator)

Evaluation of vaccines against Bovine Respiratory Syncytial Virus in cattle. Swedish farmers’ foundation for agricultural research (Stockholm) 2008-01 to 2010-12 Grant number: Kött H0750358 (PI)

Forskningen utförs i samarbete med nationella och internationella partners såsom Statens Veterinärmedicinska anstalt (SVA), Växa Sverige AB, Gård och Djurhälsan AB, Uppsala Universitet, Akademiska sjukhuset, National Veterinary School of Toulouse, (ENVT), French National Institute for Agrigultural Research (INRA), French Agency for Food, Environmental and Occupational Health & Safety (ANSES) Frankrike, The Pirbright Institute (TPI), Storbritannien, University of Glasgow, Skottland, University of Maastricht, Nederländerna och Friedrich-Loeffler-Institut (FLI), Tyskland.

1. Hägglund S, Laloy E, Näslund K, Pfaff F, Eschbaumer M, Romey A, Relmy A, Rikberg A, Svensson A, Huet H, Gorna K, Zühlke D, Riedel K, Beer M, Zientara S, Bakkali-Kassimi L, Blaise-Boisseau S, Valarcher JF. (2020) Model of persistent foot-and-mouth disease virus infection in multilayered cells derived from bovine dorsal soft palate. Transbound Emerg Dis. Jan;67(1):133-148. doi: 10.1111/tbed.13332.
2. Salem E, Hägglund S, Cassard H, Corre T, Näslund K, Foret C, Gauthier D, Pinard A, Delverdier M, Zohari S, Valarcher JF, Ducatez M, Meyer G. Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle. (2019) J Virol. Mar 21;93(7). pii: e01853-18. doi: 10.1128/JVI.01853-18.
3. Pfaff F, Hägglund S, Zoli M, Blaise-Boisseau S, Laloy E, Koethe S, Zühlke D, Riedel K, Zientara S, Bakkali-Kassimi L, Valarcher JF, Höper D, Beer M, Eschbaumer M. Proteogenomics Uncovers Critical Elements of Host Response in Bovine Soft Palate Epithelial Cells Following In Vitro Infection with Foot-And-Mouth Disease Virus (2019) Viruses. Jan 12;11(1). pii: E53. doi: 10.3390/v11010053.
4. Delabouglise A, James A, Valarcher JF, Hägglund S, Raboisson D, Rushton J. Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France. (2017) PLoS One. Dec 5;12(12):e0189090. doi: 10.1371/journal.pone.0189090.
5. Hägglund S, Blodörn K, Näslund K, Vargmar K, Lind SB, Mi J, Araínga M, Riffault S, Taylor G, Pringle J, Valarcher JF. (2017) Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virus-Insights in pathogenesis and perspectives for new treatments. PLoS One. Oct 16;12(10):e0186594. doi: 10.1371/journal.pone.0186594
6. Malmsten A, Malmsten J, Blomqvist G, Näslund K, Vernersson C, Hägglund S, Dalin AM, Ågren EO, Valarcher JF. (2017) Serological testing of Schmallenberg virus in Swedish wild cervids from 2012 to 2016. BMC Vet Res. Apr 4;13(1):84. doi: 10.1186/s12917-017-1005-8.
7. Hägglund S and Valarcher JF. (2016) Bovine respiratory syncytial virus. In: Molecular Detection of Animal Viral Pathogens (ed. Liu D), CRC Press, ISBN 9781498700368
8. Blodörn K, Hägglund S, Gavier-Widen D, Eléouët JF, Riffault S, Pringle J, Taylor G, Valarcher JF. (2015) bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity. BMC Vet Res. Mar 25;11:76. doi: 10.1186/s12917-015-0389-6.
9. Valarcher JF, Hägglund S, Juremalm M, Blomqvist G, Renström L, Zohari S, Leijon M, Chirico J. (2015) Tick-borne encephalitis OIE Scientific and Technical Review. Aug;34(2):453-66.
10. Anderson J, Hägglund S, Bréard E, Riou M, Zohari S, Comtet L, Elvander M, Blomqvist G, Zientara S, Valarcher JF. (2014) Strong protection induced by an experimental DIVA subunit vaccine against bluetongue virus serotype 8 in cattle. Vaccine. Nov 20;32(49):6614-21. doi: 10.1016/j.vaccine.2014.09.066. Epub 2014 Oct 11.
11. Blodörn K, Hägglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, Eléouët JF, Riffault S, Taylor G, Valarcher JF. (2014) Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies. PLoS One. Jun 19;9(6):e100392. doi: 10.1371/journal.pone.0100392.
12. Hägglund S, Hu K, Blodörn K, Makabi-Panzu B, Gaillard AL, Ellencrona K, Chevret D, Thorpe M, Hellman L, Lövgren-Bengtsson K, Riffault S, Taylor G, Valarcher JF., Eléouët JF (2014) Characterization of an experimental vaccine for bovine respiratory syncytial virus. Clin Vaccine Immunol. Jul;21(7):997-1004. doi: 10.1128/CVI.00162-14.
13. Anderson J, Breard E, Lovgren Bengtsson K, Gronvik KO, Zientara S, Valarcher JF, Hägglund S. (2014) Purification, stability, and immunogenicity analyses of five bluetongue virus proteins for use in development of a subunit vaccine that allows differentiation of infected from vaccinated animals. Clin Vaccine Immunol. Mar;21(3):443-52.
14. Anderson J, Hägglund S, Breard E, Comtet L, Lövgren Bengtsson K, Pringle J, Zientara S, Valarcher JF (2013) Evaluation of the Immunogenicity of an Experimental Subunit Vaccine That Allows Differentiation between Infected and Vaccinated Animals against Bluetongue Virus Serotype 8 in Cattle. Clin Vaccine Immunol. Aug;20(8):1115-22..
15. Hägglund S, Hu KF, Vargmar K, Poré L, Olofson AS, Blodörn K, Anderson J, Ahooghalandari P, Pringle J, Taylor G, and Valarcher, JF (2011) Bovine respiratory syncytial virus ISCOMs – immunity, protection and safety in young conventional calves. Vaccine. Nov 3;29(47):8719-30
16. Valarcher JF, Hägglund S. (2010) Bovine coronavirus In: Infectious and Parasitic Diseases of Livestock (eds Lefèvre P.C., Blancou J., Chermette, R).
17. Liu L, Hägglund S, Hakhverdyan M, Alenius S, Larsen LE, Bélak S. (2006) Molecular epidemiology of Bovine Coronavirus based on comparative analyses of the S gene. J Clin Microbiol 44 (3) 957-960.
18. Hägglund S, Svensson C, Emanuelson U, Valarcher JF, Alenius S. (2006) Dynamics of virus infections involved in the bovine respiratory disease complex in Swedish dairy herds. Vet J. Sep;172(2):320-8.
19. Almeida R S, Domingues H G, Spilki FR, Larsen LE, Hägglund S, Bélak S, Arns C. W. (2006) BRSV subgroup B is circulating in Brazil. Vet Rec. May 6;158(18):632-4.
20. Hägglund S, Hjort M, Öhagen P, Törnqvist M, Alenius S. (2006) A six-year study on respiratory viral infections in a bull testing facility. Vet J. May;173(3):585-93
21. Hakhverdyan M, Hägglund S, Larsen LE, Belak S. (2005) Evaluation of a single-tube fluorogenic RT-PCR assay for detection of bovine respiratory syncytial virus in clinical samples. J Vir Meth 123, 195-202.
22. Hägglund S, Hu KF, Larsen LE, Hakhverdyan M, Valarcher JF, Taylor G, Morein B, Belak S, Alenius S. (2004) Bovine respiratory syncytial virus ISCOMs--protection in the presence of maternal antibodies. Vaccine 23, 646-655.

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