Medical Protein biochemistry (Jan Johansson)
How proteins assemble into functional polymers, e.g. spider silk, and disease-causing amyloid, e.g. the amyloid β-peptide (Aβ) plaques associated with Alzheimer’s disease. We are particularly interested in nature’s systems for controlling protein self-assembly and the amino acid sequence determinants of amyloid formation.
(1) The recently discovered proprotein chaperone Brichos as a general anti-amyloid factor, and its mechanisms of action in prosurfactant protein C biosynthesis.
(2) Design and analysis of helix stabilizers as inhibitors of Aβ amyloid formation.
(3) Molecular mechanisms in spider silk formation and studies of recombinant spider silk.
Kerstin Nordling, Hanna Willander, My Hedhammar, Anna Rising, Siwei Peng, Urmimala Chatterjee, Jenny Presto, Mona Widhe, Ronnie Jansson, Erik Hermansson.
firstname.lastname@example.org, tel. +46-18-4714065.
Tools and techniques
Design, production and isolation of recombinant proteins, protein structural studies and protein interactions by spectroscopic techniques and mass spectrometry, various techniques to study amyloid fibril formation (and inhibition thereof) in the test tube and in cells, cell models of
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