Sveriges lantbruksuniversitet
Swedish University of Agricultural Sciences
Sveriges lantbruksuniversitet
Swedish University of Agricultural Sciences

Institutionen för husdjursgenetik

 
Sveriges lantbruksuniversitet
Swedish University of Agricultural Sciences
Institutionen för husdjursgenetik

Functional evaluation of DNA variation related to growth in chicken

Empirical data from experimental chicken populations characterised phenotypically and genetically (e.g. genome resequencing and high-density genotyping) are available for this project. Identification of mutations, pathways and genetic interactions underlying complex traits can improve our biochemical understanding and could be highly valuable for human medicine, agriculture and other areas of biology.

 This project aim to functionally evaluate genetic variation located within identified quantitative trait loci. A good general understanding of molecular biology, programming skills and efficient utilisation of available bioinformatic resources are valuable components in this process.
 

 

For more information

Contact:

Stefan Marklund, Assoc. Prof Stefan.Marklund@hgen.slu.se 

Örjan Carlborg, Professor Orjan.Carlborg@hgen.slu.se

You can also find more information about our group at http://www.computationalgenetics.se and http://www.lcb.uu.se

Selected recent publications:

* Carlborg, Ö. and Haley, C. Epistasis: too often neglected in complex traits studies? Nature Reviews Genetics 2004 5: 618-625.

* Carlborg, Ö., Jacobsson, L., Åhgren, P., Siegel, P., Andersson, L. Epistatsis and the release of genetic variation during long-term selection. Nature Genetics 2006 38:418-20.

* Gjuvsland, A., Hayes, B., Plahte, E., Omholt, S., Carlborg, Ö. Statistical epistasis is a generic feature of gene regulatory networks. Genetics 2007 175:.411-420.

* Le Rouzic, A., Siegel, P. and Carlborg, Ö. Phenotypic Evolution from Genetic Polymorphisms in Radial Network Architectures. BMC Biology 2007, 5:50.

* Alvarez-Castro, J., le Rouzic, A. and Carlborg, Ö. How to perform meaningful estimates of genetic effects. PLOS Genetics 2008 May 2; 4(5):e1000062

* Le Rouzic, A., Alvarez-Castro, J. and Carlborg, Ö. Dissection of the genetic architecture of body weight in chicken reveals the impact of epistasis on domestication traits. Genetics 2008 179:1591-1599.

Sidan uppdaterad: 2010-05-11.
 
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Fakulteten för veterinärmedicin och husdjursvetenskap  Organisationsnummer 202100-2817
Postadress  Box 7084  750 07 Uppsala • Telefon  018 - 67 10 00

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