Understanding the biocontrol mechanisms of plant diseases
Fungi causing diseases on crop plants have traditionally been controlled by chemical measures. Biological control of plant disease is an attractive alternative to fungicide use for managing plant diseases and sustainable crop production which is expected to play an increasing and important role in the future both in ecologically farmed crops and in integrated pest management.
Currently, I am interested in working on fungal biocontrol agents (Trichoderma atroviride and Clonostachys rosea) and their interactions with fungal plant pathogens (Botrytis cinerea, Rhizoctonia solani and Fusarium graminearum) and host plants (Arabidopsis, Tomato and Barley), to understand the biocontrol mechanisms of plant diseases, using gene knockout approach.
I am also interested in understanding the interaction mechanisms between fungal and bacterial biocontrol agents (BCAs), and between biocontrol agents and fungicides in order to develop the consortia of biological control agents, and possibility to combine BCAs with lower dose of fungicides to control the complex plant diseases.
- Tzelepis, G., Akira Hosomi, A., Hossain, T.J., Hirayama, H., Dubey, M., Jensen, D.F., Suzuki, T., Karlsson, M. (2014). Endo-b-N-acetylglucosamidases (ENGases) in the fungus Trichoderma atroviride: Possible involvement of the filamentous fungi-specific cytosolic ENGase in the ERAD process. Biochemical and Biophysical Research Communications 449, 256-261.
- Dubey, M.K., Jensen, D.F. and Karlsson M. (2014). Involvement of an ATP-binding cassette pleotropic drug transporter in xenobiotic tolerance and antagonism in fungal biocontrol agent Clonostachys rosea IK726. Molecular Plant-Microbe Interaction.
- Dubey, M.K., Broberg, A., Sooriyaarachchi, S., Ubhayasekera, W., Jensen, D.F. and Karlsson M. (2013). The glyoxylate cycle is involved in pleotropic phenotypes, antagonism and induction of plant defence responses in the fungal biocontrol agent Trichoderma atroviride. Fungal Genetics and Biology, 58-59, 33-41.