Biochemistry, continuation

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You have until 2023-04-04

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Academic year 2021/2022

Biochemistry, continuation (KE0073-30177)

2022-02-18 - 2022-03-23

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KE0073 Biochemistry, continuation, 7.5 Credits

Biokemi, fortsättningskurs

Subjects

Biology Chemistry

Education cycle

Bachelor’s level

Modules

Title	Credits	Code
Mandatory elements	2.0	0102
Exam	5.5	0103

Advanced study in the main field

First cycle, has less than 60 credits in first-cycle course/s as entry requirementsBachelor’s level (G1F)

Grading scale

Language

Swedish

Prior knowledge

Knowledge and skills in fundamentals of chemistry corresponding to 15 hp

Objectives

The aim of the course is to give advanced knowledge and skills within biochemistry.



On completion of the course, the student should be able to:

1. account at a general level for different technologies for analysis and structural studies of proteins

2. describe and illustrate principles of enzyme catalysis, kinetics and regulation

3. identify structural and functional parts in protein molecules and relate them to the biological function of the protein (e g catalytic mechanism at enzymes, receptor mechanism)

4. account at a general level for methods to generate and use biological information (gene technology and bioinformatics)

5. describe how lipids carbohydrates and proteins are metabolized and synthesised

6. present and discuss metabolism in connection with overweight nutritional intake, training, starvation, diabetes and cancer

7. relate symptoms on deficit/surplus/genetic defects to metabolic disturbances at a biochemical level

8. present biochemical problem-solving in the form of seminars

9. carry out processing and analysis of data from biochemical experiments and to present these in writing

Content

Lectures, teaching sessions, computer practicals, seminars and exercises are used in the course. Some activities are conducted in small groups, while others are not.

Roll call and course introduction, seminars, computer practicals, and group exercises are compulsory components.

Written and oral presentations are carried out through presenting results from computer practicals , seminars and group exercises. The course consists of both biochemical theory and of solving biochemical problem.

The following items are treated in lectures, teaching sessions, seminars and laboratory sessions:

- technologies for purification, analysis and structural studies of proteins

- gene technology, bioinformatics, "omics" (genomics, transcriptomics, proteomics, metabolomics), recombinant gene expression

- enzymes: catalytic mechanisms, regulation of activity, allostery, efficiency, specificity, enzyme-assays

- carbohydrate metabolism: the pentose phosphate pathway, gluconeogenesis, the glycogen, reciprocal regulation

- metabolism of fats, lipids, amino acids, proteins, nucleotides, nitrogen metabolism

- integration of metabolism: nutritional intake, homeostasis, hormonal control, body weight, BMI, overweight, training, starvation, alcohol

-membrane channels, pumps, signal transduction, sensory systems, receptors

Formats and requirements for examination

Examination formats: Written examination and approved compulsory activities .

Passing the course requires: Approved examination, approved participation in compulsory activities.

• If the student fails a test, the examiner may give the student a supplementary assignment, provided this is possible and there is reason to do so.
• If the student has been granted special educational support because of a disability, the examiner has the right to offer the student an adapted test, or provide an alternative assessment.
• If changes are made to this course syllabus, or if the course is closed, SLU shall decide on transitional rules for examination of students admitted under this syllabus but who have not yet passed the course.
• For the examination of a degree project (independent project), the examiner may also allow the student to add supplemental information after the deadline. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Other information

• The right to take part in teaching and/or supervision only applies to the course date to which the student has been admitted and registered on.
• If there are special reasons, the student may take part in course components that require compulsory attendance at a later date. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Additional information

The entry requirements can be achieved e g by having followed the courses in basic chemistry I and II comprising in total 22.5 credits with at least 15 credits passed results.

Some learning activities may be conducted in English.

Responsible department

Department of Molecular Sciences

Further information

After completion of the course students should be able to:

1. Examine and explain the relationships between structure of a macromolecule, especially of a protein, its biochemical activity and its functional role in a particular biochemical pathway.
2. Examine and explain the role of a particular biochemical pathway in normal development and disease, at the cellular and organismal levels.
3. Discuss basic metabolism and integrate major metabolic processes into health and disease states.

Learning goal	Grading criteria
	3 (G)	4 (VG)	5 (MVG)
1	Describe how protein activity can be regulated by altering its structure.	Describe and illustrate how protein activity and the whole biochemical pathway can be regulated by altering protein structure.	Correlate protein structure, protein activity and biochemical pathway in the context of normal development and disease, at the cellular and organismal levels.
2	Describe the role of basic biochemical pathways in normal development and disease.	Connect cellular and organismal roles of biochemical pathways in the context of normal development and disease.
3	Describe major metabolic processes and how they are regulated.	Compare major metabolic processes in health versusdisease.	Reflect on health and disease states from metabolome viewpoint.

NB! All compulsory parts of the course should be fulfilled for all grades; i.e. participation in all computer practicals, group exercises, invited seminars and student seminar presentations.

1) Biochemistry
**Link: **

https://www.macmillanlearning.com/ed/uk/product/Biochemistry--9th-edition/p/1319114652

**Authors:** J.M. Berg, J.L. Tymoczko, G.J. Gatto, Jr., L. Stryer 
**ISBN: **978-1-319-11467-1 
**Comments:** Chapter references are given to the 9th edition. Previous editions (8th and 7th) should also work.