VM0148, Clinical genomics in veterinary medicine, 7.5 Hp
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Syllabus

Finalized by: PN-VH, 2025-11-11
Valid from : Spring semester 2027 (2027-01-18)

Level

First cycle (G2F)

Main field of study

Veterinary Medicine

Grading Scale

The grade requirements within the course grading system are set out in specific criteria. These criteria must be available by the course start at the latest.

Course language

English

Entry Requirements

Objectives

The aim of the course is to give knowledge about the composition and function of the genomes of domestic animals, as well as the role of genetic and epigenetic factors in development of disease, malformations and developmental disorders.

Upon successful completion of the course, students will be able to

• describe the structure and function of genomes of domestic animals and explain basic concepts for gene expression and how disturbance of gene expression can increase the risk of disease;
• describe the clinical significance of epigenetic signatures and methods for their analysis;
• account for identification and significance of different genetic factors for the onset of hereditary diseases;
• explain the principles of mitochondrial inheritance and describe associated mitochondrial diseases;
• account for methods for molecular genetic diagnostics and its implementation;
• explain the principles and applications of cloning, transgenesis, genome editing, and gene therapy in animals,
• discuss the ethical, societal, and regulatory implications of gene editing technologies;
• summarize scientific literature on genetics in veterinary medicine, molecular genetics and clinical genomics.

Content

Subject-related content
The course covers the structure of genes and genomes, chromatin organization, regulation of gene expression, and various types of mutations and chromosomal alterations. Methods for identifying genetic and epigenetic risk factors and diagnosing them, including clinical sequencing are included. The course provides an overview of current molecular medical techniques and their applications. The course also addresses cloning, transgenic animal models, and advanced genetic modification methods, including CRISPR/Cas9.

The course introduces how information about genes, genomes, and epigenomes can be accessed through biological databases. It also explores how genetic testing can be applied to promote healthier animal breeding, and discusses ethical issues in clinical genetic diagnostics.

Teaching formats
To further student learning and promote discussion, a variety of methods are used: Teaching is conducted through online lectures, exercises, and dry lab activities.

The course focuses on the following generic competencies:
Information competence, critical thinking, problem solving, scientific methods, digital competence, oral communication, written communication, ethical approach, and reflective approach.

The following components are compulsory:
Certain exercises and dry lab components.

Examination Formats and Requirements for Passing the Course

Passed oral examination. Approved participation in compulsory components.

Responsible Department/Equivalent

Department of Animal Biosciences

Supplementary information

The Course Replaces

VM0130

Other Information

All teaching within the course is given online, with no mandatory on-campus meetings. It is a necessity for the student to have access to a computer and an internet connection.

The entry requirement of 4.5 credits genetics may be fulfilled through completed SLU course:

• Basic medical biology and Population medicine, or
• Breeding 1, or
• Breeding 2, or
• Basic Animal Breeding and Genetics, or
• Animal breeding and genetics, or
• Animal Breeding

To assimilate the course content, students should have a basic knowledge of genetic mechanisms (structure of the genome, replication, transcription), RNA-processing, translation, regulation of gene expression, and basic epigenetic mechanisms, basic genetics and population genetics.