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Carolina Vogs

Carolina Vogs
I am a researcher in (eco)toxicology at the Department of Biomedical Science and Veterinary Public Health, Pharmacology and Toxicology Unit. My background is computational (eco)toxicology, specifically with the focus to link chemical exposure to adverse health outcome.

Presentation

My research interests relate to the understanding and modelling of toxicokinetic and toxicodynamic processes of chemicals. Toxicokinetics explain “how a chemical gets into a body and what happens to it in the body”, while toxicodynamics describe “what the chemical does to the body”. At SLU, I am working on the establishment of predictive tools that can be used for human exposure assessment of per- and polyfluorinated alkyl substances (PFAS), thereby contributing to the question which blood PFAS concentrations can be regarded as safe from a health point-of-view. Much of my previous research has been on understanding the development of toxicity in algae and zebrafish embryo. Currently, I am also affiliated at Karolinska Institutet to further investigate toxicity mechanisms of PFAS and other chemicals in zebrafish embryo (more information on ongoing projects).

Teaching

I am supervising master students in the physiologically based pharmacokinetic modelling course and zebrafish embryo laboratory course. I have further experiences as supervisor for bachelor and master students. Please contact me, if you are interested in conducting a thesis project.

Background

PostDoc in Toxicology, Karolinska Institutet, Institute of Environmental Medicine

PhD in Ecotoxicology, Helmholtz-Centre for Environmental Research/RWTH Aachen University

Diploma in Geoecology, Technical University of Braunschweig

Selected publications

Tal, T., Vogs, C. (2021): Invited Perspective: PFAS Bioconcentration and Biotransformation in Early Life Stage Zebrafish and Its Implications for Human Health Protection. Environ. Health Perspect. 129 (7), 071304

Krais, A.M., Essig, J. Y., Gren, L. Vogs, C., Assarsson, E., Dierschke, K., Nielsen, J., Strandberg, B., Pagels, J., Broberg, K., Lindh, C.H., Gudmundsson, A., Wierzbicka, A. (2021): Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO). Int. J. Environ. Res. Public Health INT J ENV, 18(12).

Lungu-Mitea, S., Vogs, C., Carlsson, G., Montag, M. Friberg, K., Oskarrson, A., Lundqvist, J. (2021): Modelling bioavailable concentrations in zebrafish cell lines and embryos increases the correlation of toxicity potencies across test systems. Environ. Sci. Technol. 55(1), 447-457.  

Cunha, V.*, Vogs, C*., Le Bihanic, F., Drej, K. (2020): Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos. Environ. Int. 143. 105913.*contributed equally to this work

Xu., Y., Fletcher, T., Pineda, D., Lindh, CH., Nilsson, C., Glynn, A., Vogs, C., Norström, K., Lilja, K., Jakobsson, K., Li, Y. (2020): Serum Half-Lives for Short-and Long-Chain Perfluoroalkyl Acids after Ceasing Exposure from Drinking Water Contaminated by Firefighting Foam. Environ. Health Perspect., 128(7). 077004.

Vogs, C., Johanson, G, Näslund, M., Wulff, S., Sjödin, M., Hellstrandh, M., Lindberg, M., Wincent, E., (2019): Toxicokinetics of perfluorinated alkyl acids influences their toxic potency in the zebrafish embryo (Danio rerio). Environ. Sci. Technol.  53(7), 3898-3907.

Kühnert, A., Vogs, C., Serwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W., (2017): Biotransformation in the zebrafish embryo –temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene. Environ Poll., 230, 1 - 11.

Klüver, N., Vogs, C., Altenburger, R., Escher, B., Scholz, S., (2016): Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test. Chemo, 50(14), 164 - 173.

Vogs, C., Altenburger, R., (2016): Time-dependent effects in algae for chemicals with different adverse outcome pathways: A novel approach. Environ. Sci. Technol., 50(14), 7770 - 7780.

Massei, R., Vogs, C., Renner, P., Altenburger, R, Scholz, S., (2015): Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): the role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects. Aquat. Toxicol., 166, 36 - 41.

Vogs, C., Kühnert, A., Hug, C., Küster, E., Altenburger, R., (2015): A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus. Environ. Toxicol. Chem., 32(5), 1161 – 1172.

Faust, M., Vogs, C., Rotter, S., Wöltjen, J., Höllrigl-Rosta, A., Altenburger, R., (2014): Comparative assessment of plant protection products: how many cases will regulatory authorities have to answer?, Env. Sci. Eur., 26(1): 11

Kühnert, A., Vogs, C., Altenburger, R., Küster, E., (2013): The internal concentration of organic substances in fish embryos – a toxicokinetic approach. Environ. Toxicol. Chem., 32 (8), 1819-27.

Liu, Z., Flury, M., Harsh, J.B., Mathison, J.B., Vogs, C., (2013): Colloid mobilization in an undisturbed sediment core under semiarid recharge rates. Water Resour. Res., 49 (8), 4985 – 4996.

Vogs, C., Bandow, N., Altenburger, R., (2013): Effect propagation in a toxicokinetic/ toxicodynamic model explains delayed effects on the growth of unicellular green algae Scenedesmus vacuolatus. Environ. Toxicol. Chem., 32 (5), 1161 – 1172.


Contact

Researcher at the Department of Biomedical Science and Veterinary Public Health; Pharmacology and Toxicology Unit
Telephone: +4618673143
Postal address:
BVF, Avd för farmakologi och toxikologi, Box 7028
75007 UPPSALA
Visiting address: Ulls väg 26, Uppsala