I am a Bioinformatician with experience in the fields of bacterial, fungal and oomycete genomics. My areas of expertise include genome assembly, genome annotation, comparative genomics, population genomics, metagenomics and transcriptomics. I am currently analysing the genomes of oomycetes and their plant hosts in order to determine the major pathways that regulate pathogenicity and persistence of these organisms.
I am currently working on the genomics of the tropical pathogen, Phytophthora colocasiae that causes leaf blight in taro. Our main focus is to understand the mechanisms of pathogenicity and for this we are analysing the transcriptomes of infected plants. Candidate genes involved in pathogenicity will be tested for virulence in the lab. We are also keen to understand host range differences between species of Phytophthoras. We will compare the genome of the narrow-host-range pathogen, P. colocasiae to closely related species that have broad host-range.
Postdoctoral Research: CSIR Senior Research Associate, CSIR Indian Institute of Chemical Biology, India, Genomics of Endophytic fungus, Rhodotorula mucilaginosa, April 2016 – November 2017
Postdoctoral Research: CSIR Research Associate, CSIR Indian Institute of Chemical Biology, India, Genomics of cyanobacteria, April 2013 – March 2016
PhD in Bioinformatics and Computational Biology
University of Idaho| Moscow, Idaho August 2007 – October 2011
Supervisor: Professor Eva Top
Thesis Title: Comparative genomics of environmental broad-host-range plasmids
● Vetukuri RR, Kushwaha SK, Sen D, Whisson SC, Lamour KH,
Grenville-Briggs LJ. Genome Sequence Resource for the Oomycete Taro Pathogen Phytophthora colocasiae. Mol Plant Microbe Interact. 2018 Sep;31(9):903-905.
● Panda A, Sen D, Ghosh A, Gupta A, Chandrababunaidu MM, Mishra GP, Singh D, Ye W, Tyler BM, Tripathy S: A lightweight genomic resource and analytic platform for draft oomycete genomes. Mol Plant Pathol. 2016 Oct doi: 10.1111/mpp.12505.
● Sen D, C. J. Brown, E. M. Top and J. M. Sullivan. Inferring the evolutionary history of IncP-1 plasmids despite incongruence among backbone gene trees. Mol Biol Evol. 2013 Jan;30(1):154-66.
● Sen, D., G.A. Van der Auwera, L.M. Rogers, C.M. Thomas, C.J. Brown and E.M. Top. 2011. Broad-host-range plasmids from agricultural soils have IncP-1 backbones with diverse accessory genes. Appl. Environ. Microbiol. 77: 7975–7983.