Are migrating roundworm larvae part of the etiology behind respiratory symptoms and impaired performance in young trotting horses

Background

The horse roundworm, Parascaris spp, primarily infects foals, but has also been suggested to be part of the etiology behind mild equine asthma (EA) in young trotting horses. Mild equine asthma affects about 10% of young trotting and galloping horses and contributes to large financial losses for horse owners. The aim of the project is to develop a diagnostic test to investigate whether the migration of roundworm larvae through the horse's lungs is a contributing cause of reduced performance and EA.

Project Overview

We will study circulating biomarkers by analyzing microRNAs in blood and lung lavage samples from horses with a natural roundworm infection. MicroRNAs are enclosed in extracellular vesicles which are the communication channel of cells. These vesicles are released from cells or the parasite into the bloodstream and can be used to diagnose the stage of the parasite in the lung. We will follow young horses with a natural roundworm infection with serum samples and lung lavage samples for 12 months. The goal is to develop an individual-based roundworm diagnosis that will reduce the use of deworming agents and thus less selection for resistant parasites.

Aim with the project

The goal is to develop new diagnostics for early detection of roundworm infection in order to optimize the timing of treatment against roundworm, but also to make the correct diagnosis for the cause of equine asthma and thus offer the right treatment for these horses.