Winners of the prize for the best scientific peer-reviewed article published by a CRU member within reproductive biology 2021-2022

You can read more about the articles below and you can listen to Emmanouil and Ida at the CRU annual networking meeting (21 August) when they will talk about their articles.

Impaired leptin signaling causes subfertility in female zebrafish

Emmanouil Tsakoumis, Ehsan Pashay Ahi, Monika Schmitz.

This study describes, for the first time, an important role of leptin in female reproduction in zebrafish. The article stands out for its thorough investigation of a loss-of-function leptin receptor zebrafish strain on the physiological and molecular level, for the clear presentation of methods and results, and for a balanced discussion and conclusions. By providing novel insights into female reproduction in fish and involving scientists from both UU and SLU, it lies at the core of CRU’s scope.

You can read the full paper here:

Tsakoumis, E., Ahi, E. P., & Schmitz, M. (2022). Impaired leptin signaling causes subfertility in female zebrafish. Molecular and cellular endocrinology, 546, 111595. https://doi.org/10.1016/j.mce.2022.111595

Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model

Ida Hallberg , Sara Persson, Matts Olovsson, Marc-André Sirard, Pauliina Damdimopoulou, Joëlle Rüegg, Ylva C.B. Sjunnesson.

This study demonstrates, for the first time, consequences of Perfluorooctane sulfonate (PFOS) exposure during oocyte maturation for early embryonic development. The article stands out for its thorough characterisation of functional, morphological and molecular effects of PFOS in an innovative and human-relevant bovine in vitro model. The findings are relevant for human reproductive health and are the product of a collaboration between SLU and UU, thus lying at the core of CRU’s scope.

You can read the full paper here:

Hallberg, I., Persson, S., Olovsson, M., Sirard, M. A., Damdimopoulou, P., Rüegg, J., & Sjunnesson, Y. C. B. (2021). Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model. Toxicology, 464, 153028. https://doi.org/10.1016/j.tox.2021.153028