Anthelmintic resistance in the equine roundworm
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Global goals
- 3. Good health and well-being
- 12. Responsible consumption and production
Short summary
The roundworm, Parascaris univalens, is the horse's largest intestinal parasite and very common in foals and young horses. In this research project, we are investigating a possible mutation in the parasite that may be behind the resistance – and horses are being recruited for the study!
The roundworm Parascaris univalens is the horse’s largest intestinal parasite and is very common in foals and young horses. In this research project, we are investigating a possible mutation in the parasite that may underlie the resistance.
Roundworm infection is very common in foals and young horses. Symptoms of roundworm infection may include reduced appetite and general condition, nasal discharge, coughing, a rough coat, and poor growth. If the foal has a very heavy parasite burden, this can lead to obstruction/constipation of the small intestine, resulting in severe colic and potentially death.
Resistance to deworming agents reported
In general, foals are dewormed against roundworm several times during their first year of life. Previously, all available deworming drugs were effective against roundworm, but about 15 years ago the first report of resistance to ivermectin (Ivomec® and others) was published. Since then, the problem has expanded, and today there are also reports of resistance to benzimidazole (Axilur®) or pyrantel (Banminth® and others).
Aim and objective
This project aims to increase our understanding of how the horse roundworm develops resistance to deworming drugs. This knowledge may help identify new target molecules for future treatments and support the development of biomarkers that enable early detection of resistance.