P000043, Biology of Genomes, 7.5 Hp
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Kursplan

Fastställd av: Fun-VH, 2023-04-18
Giltig från och med : Andra halvår 2023 (2023-07-01)

Nivå

Forskarnivå

Betygsskala

Kraven för kursens olika betygsgrader framgår av betygskriterier, som ska finnas tillgängliga senast vid kursstart.

Kursspråk

Engelska

Behörighetskrav

Mål

The course intends to provide advanced knowledge of theory and methods for studies of eukaryotic genomes, including their organization and evolution. There is a focus on animal genomics, but theoretical and methodological aspects of the course are applicable on many different organisms.

On completion of the course, the student should be able to:

• systematically describe and analyse structure, diversity and evolution of eukaryotic genomes and genes,
• describe and analyse various types of genetic variation,
• illustrate and distinguish between the types of genetic recombination and recite some of its applications in genome analysis,
• apply and critically process key features of molecular phylogenetic / -genomic and evolutionary analysis,
• comprehensively describe the different types of RNA in the transcriptome and understand principles for transcriptional regulation and gene function,
• describe and plan different approaches for functional analysis of genes and genomes,
• explain and evaluate the principles of whole genome mapping and comparative genomics to identify genes and loci underlying mendelian and quantitative inherited diseases as well as important phenotypic traits,
• explain epigenetic and epigenomic markers and methods for the analysis of these,
• describe and explain the concept of genome editing and transgenic animals,
• compile data, apply and explain basic statistics relevant to genome analysis,
• independently search for, summarize, interpret, and critically assess scientific articles in genetics, molecular genetics, and genomics,
• integrate knowledge in molecular genetics and biotechnology to solve complex problems of relevance for genome analysis,
• summarize the importance of and how bioinformatics can be used in genome analysis,
• discuss how the content of the course is relevant to the student´s own research project.

Innehåll

The course is based on lectures, exercises, and group discussions. The contents build largely on animal genome research. Theoretical teaching is for the most part directly applicable also within for example human or plant genetics. Genome science is rapidly evolving, and the course is based on current state-of-the-art methodology and research.

Computer exercises and group discussions will cover:

• structural and comparative genomics,
• molecular evolution and phylogenetics/-genomics,
• genomic diversity and genetic variation,
• functional genomics,
• gene mapping, GWAS, and QTL analysis,
• epigenetics/-genomics,
• genome editing and transgenic animals.

The aim of the computer exercises is to give the students useful tools for basic genetic and genomic analyses. Therefore, the computer exercises use free and open-source software that the student can download and use on their own laptop. In addition to the written and the oral examination, compulsory components occur within computer exercises and group assignments.

Examinationsformer

Passed participation including oral presentations and written reports in compulsory course modules. Written and oral examination.

Ansvarig institution eller motsvarande

Institutionen för husdjursgenetik

Kompletterande uppgifter

Övrig information

The course is given jointly with the advanced course Genome Analysis (BK0002), 15 credits. The schedule is planned as part time. Compulsory exercises (eg. group discussions, and computer exercises) could, if needed, be offered as digital solutions.