I work with the development and application of methods to get a better understanding of the molecular and toxicological interactions of chemical and toxic hazards. Cell-based in vitro assays are used to study the effects of bioactive chemicals in various sources like water, food, soil etc.
I assist and train students in cell lab/lab to perform bioassays, follow GLP practices in both sterile and non-sterile conditions.
Johan Lundqvist, PhD, Associate Professor of Molecular Toxicology
Agneta Oskarsson, PhD, Professor Emeritus
Publikationer i urval
Selin, E et al. (2022). An in vitro-based hazard assessment of liquid smoke food flavourings Archives of Toxicology, 96 (2) . ss.601-611. DOI:10.1007/s00204-021-03190-1
Oskarsson, A et al. (2021). Assessment of source and treated water quality in seven drinking water treatment plants by in vitro bioassays – Oxidative stress and antiandrogenic effects after artificial infiltration. Science of the Total Environment, 758 DOI:10.1016/j.scitotenv.2020.144001
Celma Tirado, A et al. (2021). In vitro bioanalytical assessment of toxicity of wetland samples from Spanish Mediterranean coastline Environmental Sciences Europe, 33 (1), (1) . DOI:10.1186/s12302-021-00510-1
Lundqvist, J et al. (2019). Innovative drinking water treatment techniques reduce the disinfection-induced oxidative stress and genotoxic activity Water Research, 155 ss.182-192. DOI:10.1016/j.watres.2019.02.052
Lundqvist, J et al. (2019). In vitro bioanalytical evaluation of removal efficiency for bioactive chemicals in Swedish wastewater treatment plants Scientific Reports, 9 DOI:10.1038/s41598-019-43671-z
Niss, F et al. (2018). Toxicity bioassays with concentrated cell culture media-a methodology to overcome the chemical loss by conventional preparation of water samples Environmental Science and Pollution Research, 25 (12), (12) . ss.12183-12188. DOI:10.1007/s11356-018-1656-4
Rosenmai, A et al. (2018). Effect-based assessment of recipient waters impacted by on-site, small scale, and large scale waste water treatment facilities-combining passive sampling with in vitro bioassays and chemical analysis Scientific Reports, 8 DOI:10.1038/s41598-018-35533-x
Rosenmai, A et al. (2018). Impact of natural organic matter in water on in vitro bioactivity assays Chemosphere, 200 ss.209-216. DOI:10.1016/j.chemosphere.2018.02.081
Forsberg, L et al. (2015). Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer Genome Research, 25 (10), (10) . ss.1521-1535. DOI:10.1101/gr.187823.114
Pakalapati,G (2014). Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer Nature Genetics, 46 (6), (6) . ss.624-628. DOI:10.1038/ng.2966
Pakalapati,G (2012). Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells American Journal of Human Genetics, 90 (2), (2) . ss.217-228. DOI:10.1016/j.ajhg.2011.12.009
Chiocchetti A, Pakalapati G, Duketis E, Wiemann S, Poustka A, Poustka F, Klauck SM. Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A. 2011 Jun;155A(6):1472-5. doi: 10.1002/ajmg.a.33977.
Pakalapati,G (2009). Influence of red clover (Trifolium pratense) isoflavones on gene and protein expression profiles in liver of ovariectomized rats Phytomedicine, 16 (9), (9) . ss.845-855. DOI:10.1016/j.phymed.2009.03.003