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Josefin Söder

Josefin Söder

Presentation

Leg. vet. DVM, PhD-student

Department of Anatomy, Physiology and Biochemistry, SLU


I finished my Master of Science in Veterinary Medicine in 2012 and in the same year started my PhD-education within the Future Animal Health and Welfare Initiative at SLU. I am particularly interested in obesity-related metabolic dysfunctions in dogs, which is also the topic of my PhD-project. I also enjoy working with students and currently I teach anatomy at the Department of Anatomy, Physiology and Biochemistry, SLU.

 

Obesity is a groing problem in dogs

People in the world are growing more and more obese and welfare diseases associated with our lifestyle are becoming a big problem. Even our companion dogs that share our lifestyle are becoming more obese; in fact 50% of our dogs today are overweight.

The overweight dog has an increased risk of reduced wellbeing, earlier onset of chronic diseases and a shorter life and I believe each one of these consequences motivates obesity research in dogs. The metabolism in dog besity is not as thoroughly investigated as in humans and we need a better understanding of metabolic alterations in overweight dogs for futher development of therapeutic methods.

The overall goal of the PhD-project is to investigate obesity-related metabolic dysfunctions in dogs using serum, plasma, and urine. Privately owned healthy intact male Labrador retrievers with different body contitions (i.e. from lean to overweight) have been sampled before and after a standardized meal. 

 

Publications

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge. J. Söder et al.  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180086#sec016 

Metabolic and Hormonal Response to a Feed-challenge Test in Lean and Overweight Dogs. J. Söder et al. http://onlinelibrary.wiley.com/doi/10.1111/jvim.13830/pdf

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs http://www.sciencedirect.com/science/article/pii/S1550413116301632

Validation and application of a canine-specific automated high-sensitivity C-reactive protein assay http://vdi.sagepub.com/content/27/2/182.short

Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp http://onlinelibrary.wiley.com/doi/10.1111/jvim.14799/full

Interday variation and effect of transportation on indirect blood pressure measurements, plasma endothelin-1 and serum cortisol in Standardbred and Icelandic horses J. Söder et al. https://actavetscand.biomedcentral.com/articles/10.1186/1751-0147-54-37

 

Ongoing studies and coming publications

Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs. J. Söder et al.

Plasma LC:MS metabolites in relation to different body condition scores in healty Labrador Retriever dogs. J. Söder et al.

Project collaborators

  • Ali Moazzami and Peter Agback, “Metabolomics” Chemistry and Biotechnology, SLU
  • Anna Hillström, “C-reactive protein” Clinical Chemistry, SLU
  • Bodil Ström Holst, “Reproductive parameters” Clinical Sciences, SLU
  • Eleanor Raffan, “Genetics” Metabolic Unit, Cambridge, UK

Kontaktinformation
Doktorand vid Institutionen för anatomi, fysiologi och biokemi (AFB); Avdelningen för anatomi och fysiologi
Telefon: 018-672949
Postadress:
Inst för anatomi och fysiologi, Box 7011
75007 UPPSALA
Besöksadress: VHC Huvudentré, Ulls väg 26, hus 5, plan 4, Uppsala