Anthelmintic resistance in Swedish laying hen farms

Background

The widespread use of anthelmintics to control helminth infections is widely recognized to be a contributing factor to the selection for resistance to these drugs. Resistance to all major classes of anthelmintics has been reported worldwide, particularly for BZ in ruminant gastrointestinal nematodes.

Our recent field observations have shown that some flocks remained positive for roundworm despite the administration of anthelmintics (AH). This, among other explanations, may indicate treatment failure due to the development of anthelmintic resistance (AR). This poses a growing threat to the egg industry and negatively affects the welfare and productivity of birds.

Goal

The aim of the project is to investigate the development of AR in Swedish laying hen flocks by examining samples collected from farms with signs of reduced drug efficacy. You will also have the opportunity to examine samples from flocks with multiple exposures to AH and investigate possible genetic changes due to repeated exposure.

Project description

Methods

New molecular diagnostic tool based on droplet digital PCR and DNA sequencing to identify genetic changes in genes associated with AR. This includes DNA extraction, performing ddPCR and data analysis.

Specifications

Suitable for a work of 30 credits.

Start date is flexible.

Welcome with your application!