Master thesis project in Molecular Genetics & Genomics

Project description

These suggested thesis projects focus on the identification of genetic associations and potential causative variants underlying phenotypic traits or inherited disorders in animals (mainly horse, cat, and moose). Students will analyze phenotypes and genomic datasets (SNP array genotypes or whole-genome sequencing) using established bioinformatic, genetic and statistical methods, such as GWAS, mixed-model analyses, and variant annotation.

The work includes quality control of genomic data, detection of significant association signals, examination of candidate genes within target regions, and prioritization of functional variants. Results will be interpreted in relation to biological mechanisms and their relevance for animal breeding, health, or welfare.

I am also open for students own suggestions on projects related to molecular genetics or genomics.

Examples of projects:

• Genomics of Scrotal Hernia in Horses
• Genomics of Cerebellar Abiotrophy in Gotland ponies
• Genomics of White Coat Color in Moose
• Genomics of Flat Chest in Bengal Cats
• Genomics and Measures of Equine Flexibility
• Population Genomics in Native Nordic Horse Breeds
• Genomics and 3D Data to Decode Equine Shape and Locomotion
• Imputation of Genomic Data for Parentage Analysis in Horses
• Current Situation of Genetic Disorders in Swedish Horses

Specifications

Some parts of the studies are suitable for students with knowledge in bioinformatics, R and/or Python, while other parts are more suitable for students in Animal Science or Veterinary Medicine.