Joakim Bjerketorp

Sedan 2021 arbetar jag som forskare vid Institutionen för husdjurens biovetenskaper (HBIO), SLU, inom ett universitets-industriellt samarbete finansierat av Intervacc AB (https://intervacc.se/forskning-utveckling/). Mitt huvudsakliga fokus ligger på att utveckla rekombinanta vacciner mot viktiga bakteriella sjukdomar hos häst (Streptococcus equi; Streptococcus zooepidemicus), gris (Streptococcus suis) och nöt (Staphylococcus aureus), samt tillhörande serologiska tester (ELISA) som kan skilja mellan infekterade och vaccinerade djur (DIVA). Även tidigare forskning kring nya antibiotika pågår i en begränsad omfattning.

Pågående projekt:

Utveckling av rekombinanta vacciner mot Streptococcus suis hos gris och Staphylococcus aureus hos nöt (Forskningsanslag från Intervacc).

Streptococcus equi och kvarka hos häst – vidare forskning kring Strangvac samt förbättrad diagnostik (Forskningsanslag från Intervacc).

Development of an improved and objective diagnostic tool for digital dermatitis in cattle. (Seydlitz MP Companies Foundation 2023–2025; Projektledare Anna Rosander, SLU).

Sporadisk föreläsare på olika kurser, vanligaste ämnesområden: nya och gamla antibiotika/antibiotikaresistens.

Ett tidigare projekt:

SLU–Ultupharma-projektet (https://www.ultupharma.se/) “Nya antibiotika från naturen”, med målsättningen att utveckla metoder för att upptäcka nya antibiotika verksamma mot patogena (sjukdomsframkallande) bakterier som blivit resistenta mot nuvarande behandlingar. Projektet omfattade traditionell mikrobiologisk odling, nya tekniker för att odla tidigare svårodlade mikroorganismer, samt att stimulera mikrober till att producera fler bioaktiva substanser. Urval, isolering och karakterisering av nya potentiella antibiotika mot relevanta resistenta bakterier ingick (Biobo/Ultupharma 2015–2019; Projektledare Anders Broberg, SLU).

Neutralisation of the Immunoglobulin-Cleaving Activity of Streptococcus equi Subspecies equi IdeE by Blood Sera from Ponies Vaccinated with a Multicomponent Protein Vaccine

2025 Neutralisation of the Immunoglobulin-Cleaving Activity of Streptococcus equi Subspecies equi IdeE by Blood Sera from Ponies Vaccinated with a Multicomponent Protein Vaccine

Sow vaccination with a novel recombinant protein vaccine protects piglets against Streptococcus suis infection

2025  Sow vaccination with a novel recombinant protein vaccine protects piglets against Streptococcus suis infection   Research article (Peer reviewed)

Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity-reducing agent uridine

2025  Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity-reducing agent uridine   Research article (Peer reviewed)

Digital dermatitis in Swedish dairy herds assessed by ELISA targeting Treponema phagedenis in bulk tank milk

2024  Digital dermatitis in Swedish dairy herds assessed by ELISA targeting Treponema phagedenis in bulk tank milk   Research article (Peer reviewed)

Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones

2022  Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones   Research article (Peer reviewed)

In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis

2021  In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis   Research article (Peer reviewed)

Selective Isolation of Multidrug-Resistant Pedobacter spp., Producers of Novel Antibacterial Peptides

2021  Selective Isolation of Multidrug-Resistant Pedobacter spp., Producers of Novel Antibacterial Peptides   Research article (Peer reviewed)

Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

2020  Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria   Research article (Peer reviewed)

Isolation of antibiotic-resistant bacteria in biogas digestate and their susceptibility to antibiotics

2020  Isolation of antibiotic-resistant bacteria in biogas digestate and their susceptibility to antibiotics   Research article (Peer reviewed)

Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46

2020  Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46   Research article (Peer reviewed)

Antibacterial Isoquinoline Alkaloids from the Fungus Penicillium Spathulatum Em19

2019  Antibacterial Isoquinoline Alkaloids from the Fungus Penicillium Spathulatum Em19   Research article (Peer reviewed)

Formulation and stabilization of an Arthrobacter strain with good storage stability and 4-chlorophenol-degradation activity for bioremediation

2018  Formulation and stabilization of an Arthrobacter strain with good storage stability and 4-chlorophenol-degradation activity for bioremediation   Research article (Peer reviewed)

Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2

2017  Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2   Research article (Peer reviewed)

Labradorins with antibacterial activity produced by Pseudomonas sp.

2017  Labradorins with antibacterial activity produced by Pseudomonas sp.   Research article (Peer reviewed)

Effects of di- and polysaccharide formulations and storage conditions on survival of freeze-dried Sphingobium sp.

2013  Effects of di- and polysaccharide formulations and storage conditions on survival of freeze-dried Sphingobium sp.   Research article (Peer reviewed)

Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

2009  Soft inertial microfluidics for high throughput separation of bacteria from human blood cells   Research article (Peer reviewed)

Rapid lab-on-a-chip profiling of human gut bacteria

2008  Rapid lab-on-a-chip profiling of human gut bacteria   Research article (Peer reviewed)

Advances in preservation methods: keeping biosensor microorganisms alive and active

2006  Advances in preservation methods: keeping biosensor microorganisms alive and active   Review article (Peer reviewed)

A von Willebrand factor-binding protein from Staphylococcus lugdunensis. 

2004 A von Willebrand factor-binding protein from Staphylococcus lugdunensis. Research article (Peer reviewed)

The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase

2004  The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase   Research article (Peer reviewed)

Sorting a Staphylococcus aureus phage display library against ex vivo biomaterial           

2004 Sorting a Staphylococcus aureus phage display library against ex vivo biomaterial. Research article (Peer reviewed)

A fibrinogen-binding protein of Staphylococcus lugdunensis

2004  A fibrinogen-binding protein of Staphylococcus lugdunensis   Research article (Peer reviewed)

Shotgun Phage Display - Selection for Bacterial Receptins or other Exported Proteins.

2003  Shotgun Phage Display - Selection for Bacterial Receptins or other Exported Proteins. Research article (Peer reviewed)

Phage display as a novel screening method to identify extracellular proteins.

2002 Phage display as a novel screening method to identify extracellular proteins. Research article (Peer reviewed)

A novel von Willebrand factor binding protein expressed by Staphylococcus aureus

2002 A novel von Willebrand factor binding protein expressed by Staphylococcus aureus Research article (Peer reviewed)

Novel adhesive proteins of pathogenic Staphylococci and their interaction with host proteins

2004  Novel adhesive proteins of pathogenic Staphylococci and their interaction with host proteins   Doctoral thesis