Computational Toxicology and Risk Assessment
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Publications
- - Risk för förhöjda nivåer av per- och polyfluoralkylsubstanser i animaliska livsmedel vid livsmedelsproduktion i förorenade områden i Sverige
- - A comprehensive library of lifetime physiological equations for PBK models: Enhancing dietary exposure modeling with mercury as a case study
- - Transcriptomic and functional effects from a chemical mixture based on the exposure profile in Baltic Sea salmon, on metabolic and immune functions in zebrafish embryo
- - PFAS in first-time mothers from Sweden: temporal trends and the impact from fish/seafood consumption and drinking water exposure
- - Risktermometern − riskrankning av kemikalier i dricksvatten
- - Delrapport 1. Överföring av perfluoroalkylsyror från foder och dricksvatten till livsmedelsproducerande djur, och till livsmedel från dessa djur
- - Quantitative relationships of perfluoroalkyl acids in drinking water associated with serum concentrations above background in adults living near contamination hotspots in Sweden
- - Low concentrations of perfluoroalkyl acids (PFAAs) in municipal drinking water associated with serum PFAA concentrations in Swedish adolescents
- - Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation
- - Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos
We are a multidisciplinary research group working at the interface of computational toxicology, environmental and human health, and regulatory science.
Our focus is on predictive approaches to understand and manage chemical risks, supporting both scientific progress and real-world decision-making in chemical risk assessment and risk management, aiming at protecting animal and human health. Our research integrates experimental data and mechanistic modeling to bridge the gap between external and internal exposure (toxicokinetics) and to link internal doses to biological effects across molecular, organism, and population levels (toxicodynamics). We collaborate closely with national and international partners in academia, agencies, and risk assessment networks on the following core research topics.
Emerging Contaminants & Chemical Mixtures:
We study PFAS, bisphenols, metals, oxy-PAHs, and other chemicals of concern - focusing on risk characterization based on their single and mixture exposures associated with hazard properties
Exposure Assessment:
We assess relationships between chemical exposure sources (i.e., drinking water, food) and measured concentrations in humans, livestock, and fish.
Toxicokinetics & Toxicodynamics:
We develop and apply physiologically-based kinetic (PBK) models to understand internal chemical dynamics in humans, fish, livestock animals, and model organisms such as zebrafish embryos.
Model–Experiment Integration:
We combine in vitro and in vivo assays with modeling and omics, improving the prediction of biological effects across life stages and exposure routes.
Next-Generation Risk Assessment:
We contribute to the development of data-driven, non-animal, and One Health-compatible assessment frameworks aligned with the EU chemicals strategy goals.
You want to join? We welcome PhD students, postdocs, and visiting researchers with interests in toxicology, modeling, regulatory science, environmental chemistry, or public health. Our group fosters a supportive, collaborative, and impact-driven research culture.