Daniel Hofius

Last changed: 18 January 2018

Welcome to Daniel Hofius' Lab

We have a general interest in genetic and molecular mechanisms underlying the regulation of autophagy and programmed cell death during plant-pathogen interactions.                     

Our current research focuses on the following themes:

  • Interplay of autophagy and membrane trafficking pathways during plant immunity
  • Epigenetic regulation of pathogen-triggered cell death
  • Role of autophagy in viral pathogenesis and host immunity
  • Identification of pathogen effector targets of the autophagy pathway
  • Manipulation of autophagic processes to improve pathogen and stress resistance

We apply reverse and forward genetics, biochemical and cell biological approaches, and use different bacterial, viral, and oomycete/fungal pathogens in the model plant Arabidopsis thaliana.  

We are located at the Uppsala BioCenter and are part of the Linnéan Center for Plant Biology in Uppsala, the Nordic Autophagy Network and the Transautophagy COST action. Our research is funded by the Swedish University of Agricultural Sciences (SLU), Knut-and-Alice Wallenberg (KAW) Foundation (Epifate project), Swedish Research Councils VR and FORMAS; Carl Tryggers Stiftelse (CTS), and the Federation of European Biochemical Societies (FEBS).



Professor in Molecular
Plant-Pest/Disease Interactions







Research team

• Anders Hafrén, Postdoc email
• Suayib Üstün, Postdoc email
• Sheena Rasmussen, Postdoc email

Postdoc positions

Available from 2018

PhD student position

Available from 2018

Former group members

• Ooi-kock Teh, Postdoc email
• Ramesh Vetukuri, Postdoc email
• Qinsong Liu, PhD student email
• Anton Hochmuth, MSc student email
• David Solbach, MSc student email

Selected publications

Liu Q, Vain T, Viotti C, Doyle SM, Tarkowská D, Novák O, Zipfel C, Sitbon F, Robert S, Hofius D (2017) Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation. Molecular Plant December 2017 PubMed

Hafrén A, Üstün S, Hochmuth A, Svenning S, Johansen T, Hofius D (2017) Turnip mosaic virus counteracts selective autophagy of the viral silencing suppressor HCpro. Plant Physiology 175 November 2017 PubMed

Üstün S, Hafrén A, Hofius D (2017) Autophagy as a mediator of life and death in plants.  Curr. Opin. Plant Biol. 40, 122-130

Hafrén A, Macia JL, Love AJ, Milner JJ, Drucker M, Hofius D (2017) Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles. Proc Natl Acad Sci U S A doi: 10.1073/pnas.1610687114   PubMed 

Hofius D, Li L, Hafrén A, Coll NS (2017). Autophagy as an emerging arena for plant-pathogen interactions. Curr Opin Plant Biol. 38, 117-23.   PubMed 

Mozgova I, Wildhaber T, Liu Q, Abou-Mansour E, L’Haridon F, Métraux J-P, Gruissem W, Hofius D, and Hennig L (2015). Chromatin assembly factor CAF-1 represses priming of plant defence response genes, Nature Plants, doi:10.1038/nplants.2015.127.

Munch D*, Teh OK*, Malinovsky FG*, Liu Q, Vetukuri RR, El Kasmi F, Brodersen P, Hara-Nishimura I, Dangl JL, Petersen M, Mundy J, and Hofius D (2015). Retromer contributes to immunity-associated cell death in Arabidopsis. Plant Cell, 27, 463-79. (*co-first authors)

Minina EA, Bozhkov P, and Hofius D (2014)Autophagy as an initiator or executioner of programmed cell death in plants. Trends Plant Sci., 19, 692-7.

Munch D, Rodriguez E, Bressendorff S, Park OK, Hofius D, and Petersen M (2014). Autophagy deficiency leads to accumulation of ubiquitinated proteins, ER stress, and cell death in Arabidopsis. Autophagy 10, 1579-87.

Teh OK and Hofius D (2014). Membrane trafficking and autophagy in pathogen-triggered cell death and immunity. J. Exp. Bot. 65, 1297-312.

Hackenberg T, Juul T, Auzina A, Gwizdz S, Malolepszy A, van der Kelen K, Dam S, Bressendorff S, Lorenzen A, Roepstorff P, Lehmann Nielsen K, Jørgensen JE, Hofius D, van Breusegem F, Petersen M, and Andersen SU (2013). Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell 25, 4616-26.

Hofius D, Schultz-Larsen T, Joensen J, Tsitsigiannis DI, Petersen NH, Jørgensen LB, Mattsson O, Jones JD, Mundy J, and Petersen M (2009). Autophagic components contribute to hypersensitive cell death in ArabidopsisCell 137, 773-783.


Visiting address:
Biocentrum, Room A-471
Almas Allé 5
Postal address: 
Department of Plant Biology 
PO Box 7080 
SE-750 07 Uppsala
Page editor: Daniel.Hofius@slu.se