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Maliheh Mehrshad

Maliheh Mehrshad
As a microbial ecologist working at the department of Department of Aquatic Sciences and Assessment in my research, I am utilizing the potential of large-scale “multi-omics” analysis to explore aquatic microbial communities along salinity gradient and depth profile. My research addresses the compositional variation and metabolic potential of different trophic levels in aquatic habitats (prokaryotes, viruses, microeukaryotes, and fungi). My main research interest is to understand the functional and evolutionary aspects of aquatic multi-trophic interactions through experimental manipulations of the natural community, enrichment cultures, and cultivated multi-trophic model systems.


Researcher Position          Fall 2020-ongoing

Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala, Sweden

Post-DOC Positions          Summer 2016-Fall2020                                   

-- Department of Ecology and Genetics, Limnology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden (Winter 2019-Fall 2020)

Environmental genomics and microbiology with a focus on multiplayer interactions in deep groundwater and freshwater

-- Department of Aquatic Microbial Ecology, Biology Centre CAS, Ceske Budejovice, Czech Republic (Summer 2016-Fall 2018)

Ecology and metabolic capabilities of the freshwater bacterial community and their interactions with viruses and eukaryotic flagellates

PhD in Microbiology        Fall 2011-Spring 2016

University of Tehran, Tehran, Iran                 Supervisors: Prof. MA. Amoozegar and Prof. F. Rodriguez-Valera

Thesis Title: Metagenomic survey of prokaryotes in the photic zone of the Caspian Sea

M.Sc. in Microbiology      Fall 2009 – Fall 2011

University of Tehran, Tehran, Iran                 Supervisor:  Prof. MA. Amoozegar

Thesis Title: Diversity of aerobic heterotrophic moderately halophilic and halotolerant bacteria from western coastal line of Urmia Lake with culture-dependent and culture-independent methods

B. Sc. in Molecular Biology, Microbiology       Fall 2005 – Fall 2009

University of Tehran, Tehran, Iran                  Supervisor: Prof. MA. Amoozegar

Thesis Title: Polyphasic identification of halotolerant and moderately halophilic bacteria from Aran-Bidgol Salt Lake

Selected publications

- Mehrshad. M.Ϟ, Lopez-Fernandez. M., Sundh, S., Bell. E., Simone. D., Buck. M., Bernier-Latmani. R., Bertilsson. S., Dopson. M. (2020) Energy efficiency and biological interactions define the core microbiome of deep oligotrophic groundwater. biorxive. doi:10.1101/2020.05.24.111179

- Šimek. K., Grujcic. V., Mukherjee. I., Kasalický. V., Nedoma. J., Posch. T., Mehrshad. M., Salcher. MM., (2020) Cascading effects in freshwater microbial food webs by predatory Cercozoa, Katablepharidacea and ciliates feeding on aplastidic bacterivorous cryptophytes. FEMS Microbiology Ecology fiaa121.

- Rezaei Somee. M., Dastgheib. SMM., Shavandi. M., Ghanbari Maman. L., Kavousi. K., Amoozegar. M. A., Mehrshad. M.Ϟ (2020) Distinct microbial communities along the chronic oil pollution continuum of the Persian Gulf converge with oil spill accidents. biorxive. doi:10.1101/2020.07.25.221044

- Sobat. M., Asad. S., Kabiri. M., Mehrshad. M. (2020) Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian Sea.  ResearchSquare, 10.21203/

- Garcia. SL. §, Mehrshad. M. §, Buck. M. §, Tsuji. J., Neufeld. JD., McMahon. KD., Bertilsson. S., Greening. C., Peura. S. (2020) Freshwater Chlorobia exhibit metabolic specialization among cosmopolitan and endemic populations. biorxive. doi:10.1101/2020.09.10.291559.

- Cabello-Yeves. P. J., Callieri. C., Picazo. A., Mehrshad. M., Haro-Moreno. J.M., Roda-Garcia. J., Dzhembekova. N., Slabakova. V., Slabakova. N., Moncheva. S., Rodriguez-Valera. F. (2020) Microbiome of the Black Sea water column analyzed by genome centric metagenomics. biorxive. doi: 10.1101/2020.10.30.362129

- Vavourakis. CD., Mehrshad. M., Balkema. C., Hall. RV., Andrei. AS., Ghai. R., Sorokin. DY., Muyzer. G. (2019) Metagenomes and metatranscriptomes shed new light on the microbial-mediated sulfur cycle in a Siberian soda lake. BMC Biology 17 (1), 1-20.

- Kavagutti. VS., Andrei. AS., Mehrshad. M., Salcher. MM., Ghai. R. (2019) Phage-centric ecological interactions in aquatic ecosystems revealed through ultra-deep metagenomics. Microbiome 7, 135.

- Bulzu. PA., Andrei. AS., Salcher. MM., Mehrshad. M., Inoue. K., Kandori. H., Beja. O., Ghai. R., Banciu. HL. (2019) Casting light on Asgardarchaeota metabolism in a sunlit microoxic niche. Nature microbiology 4, 1129–1137.

- Andrei. AS., Salcher. MM., Mehrshad. M., Rychtecký. P., Znachor. P., Ghai. R.  (2019) Niche-directed evolution modulates genome architecture in freshwater Planctomycetes. ISME journal 13, 1056–1071.

- Amoozegar. M. A., Mehrshad. M. (2019) book chapter: Aquibacillus, Bergey's Manual of Systematics of Archaea and Bacteria, John Wiley & Sons.

- Amoozegar. M. A., Mehrshad. M. (2019) book chapter: Salinithrix, Bergey's Manual of Systematics of Archaea and Bacteria, John Wiley & Sons.

- Mehrshad. M.Ϟ, Salcher. MM., Okazaki. Y., Nakano. S., Šimek. K., Andrei. AS., Ghai. R. (2018) Hidden in plain sight - highly abundant and diverse planktonic freshwater Chloroflexi. Microbiome 6 (1), 176.

- Vavourakis. CD., Andrei. AS.§, Mehrshad. M.§, Ghai. R., Sorokin. D., Muyzer. G. (2018) A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments. Microbiome 6 (1), 168.

- Mehrshad. M., Rodriguez-Valera. F., Amoozegar. M. A., López-García. P., Ghai. R. (2018) The enigmatic SAR202 cluster up close: shedding light on a globally distributed dark ocean lineage involved in sulfur cycling. ISME Journal 12, 655–668.

- Cabello-Yeves. P. J., Ghai. R., Mehrshad. M., Picazo. A., Camacho. A., Rodriguez-Valera. F. (2017) Reconstruction of Diverse Verrucomicrobial Genomes from Metagenome Datasets of Freshwater Reservoirs. Frontiers in Microbiology 8:2131.

- Amoozegar. M. A., Khansha. J., Mehrshad. M., Shahzadeh Fazeli. S. A., Ramezani. M., Rafael. R., Sánchez-Porro. C., Ventosa. A. (2017) Soortia roseihalophila gen. nov., sp. nov., a new taxon in the order Balneolales isolated from a travertine spring, and description of Soortiaceae fam. nov. Int J Syst Evol Microbiol 67:113120.

- Ghai. R., Mehrshad. M., Mizuno. C., Rodriguez-Valera. F. (2016) Metagenomic Recovery of Phage Genomes of Uncultured Freshwater Actinobacteria. ISME Journal 11: 304-308.

- Mehrshad. M., Amoozegar. M. A., Ghai. R., Shahzadeh Fazeli. S. A., Rodriguez-Valera. F. (2016) Genome Reconstruction from Metagenomic Data Sets Reveals Novel Microbes in the Brackish Waters of the Caspian Sea. Applied and Environmental Microbiology 82:1599–1612.

- Mehrshad. M., Amoozegar. M. A., Makhdoumi-Kakhki. A., Farahani. H., Asadi. B., Schumann. P., Ventosa. A. (2015) Halosiccatus urmianus gen. nov., sp. nov., a novel haloarchaeon from a salt lake. Int J Syst Evol Microbiol DOI: 10.1099/ijsem.0.000781.

- Mehrshad. M., Amoozegar. M. A., Makhdoumi-Kakhki. A., Rasooli. M., Asadi. B., Schumann. P., Ventosa. A. (2015) Halovarius luteus gen. nov., sp. nov., a novel extremely halophilic archaeon from Urmia salt lake, Iran. Int J Syst Evol Microbiol 65: 2420-2425.

- Amoozegar. M. A., Mehrshad. M. (2013) Inventory of new microbial taxa from Iran. Progress in Biological Sciences 3:1-26.

- Mehrshad. M., Amoozegar. M. A., Didari. M., Bagheri. M., Shahzadeh Fazeli. S. A., Schumann. P., Spröer. C., Sánchez-Porro. C., Ventosa. A. (2013) Bacillus halosaccharovorans sp. nov., a moderately halophilic bacterium from a hypersaline Iranian lake. Int J Syst Evol Microbiol 63:2776-2781.