I am senior lecturer in histophysiology and associate professor in inflammation
The aim of my research has been to identify harmful and protective mechanisms that operates during inflammatory diseases, e.g. allergy, sepsis and obesity. I am particularly interested in the role of the immune system and I have mainly focused on the ability of mast cells to regulate inflammation.
Mast cells can release substances that stimulate or suppress inflammation
Foto: Sara Wernersson (600x Toluidine blue).
Education and degree
Molecular Biology, MSc, Uppsala University, 1995
PhD, Faculty of Medicine, Uppsala University, 2000
Associate Professor, Molecular inflammation research, SLU, 2008
PhD student, Dept of Genetics and Pathology, Uppsala University, 1996-2000
Postdoctoral Fellow, Dept of Cell and Molecular Biology, Uppsala University, 2001-2004
Assistant Professor in Medical Biochemistry, Section of Biochemistry, SLU, 2005-2010
Senior Lecturer in Histophysiology, SLU, 2011-current
My current research is focused around three different areas:
- Mast cell proteases in allergic inflammation
- Cytokines as biomarkers in canine pyometra and sepsis
- Metabolism and gut microbia in overweight dogs
Söder J, Wernersson S, Hagman R, Karlsson I, Malmlöf K, Höglund K. Metabolic and Hormonal Response to a Feed-challenge Test in Lean and Overweight Dogs. J Vet Intern Med. 2016, 30:574-82.
Karlsson I, Hagman R, Johannisson A, Wang L, Södersten F, Wernersson S. Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis. Vet Immunol Immunopathol. 2016, 170:41-6.
Waern I, Karlssson I, Pejler G, Wernersson S. IL-6 and IL-17A degradation by mast cells is mediated by a serglycin:serine protease axis. Immun Inflamm Dis, 2016, 4:70-79
Karlsson I, Hagman R, Guo Y, Humblot P, Wang L, Wernersson S.Pathogenic Escherichia coli lipopolysaccharide enhance the expression of IL-8, CXCL5, and CXCL10 in canine endometrial stromal cells. Theriogenology, 2015 84:34-42
Wernersson S and Pejler G. Mast cell secretory granules – armed for battle. Nature Reviews Immunology, 2014, 14:478-94.
Waern I, Lundequist A, Pejler G, Wernersson S. Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation. Mucosal Immunol. 2013, 6:911-20. 6.