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VM0130

Clinical genomics in veterinary medicine

In this course you will learn about how changes in DNA can lead to disease in domestic animals. You will also learn about current methods to analyse DNA. The course is given as an online course in combination with a few compulsory meetings in Uppsala.

Course evaluation

The course evaluation is now closed

VM0130-30268 - Course evaluation report

Once the evaluation is closed, the course coordinator and student representative have 1 month to draft their comments. The comments will be published in the evaluation report.

Additional course evaluations for VM0130

Academic year 2021/2022

Clinical genomics in veterinary medicine (VM0130-M3268)

2022-01-17 - 2022-03-23

Syllabus

VM0130 Clinical genomics in veterinary medicine, 7.5 Credits

Veterinärmedicinsk klinisk genomik

Subjects

Veterinary Medicine

Education cycle

Bachelor’s level

Modules

Title Credits Code
Single module 7.5 0101

Advanced study in the main field

First cycle, has at least 60 credits in first-cycle course/s as entry requirements(G2F)

Grading scale

5:Pass with Distinction, 4:Pass with Credit, 3:Pass, U:Fail The requirements for attaining different grades are described in the course assessment criteria which are contained in a supplement to the course syllabus. Current information on assessment criteria shall be made available at the start of the course.

Language

English

Prior knowledge

• 60 credits veterinary medicine

or

• 60 credits animal science

or

• 60 credits biology

or

• 60 credits medicine

or

• 60 credits biomedicine

or

• 60 credits biotechnology

or

• 60 credits veterinary nursing



and 4,5 credits genetics.



Exemption granted from the general entry requirement of Swedish.

Objectives

The aim of the course is to give knowledge about the composition and function of the genomes of domestic animals, as well as the role of genetic and epigenetic factors in development of disease, malformations and developmental disorders.



On completion of the course the student should be able to:

- describe the structure and function of genomes of domestic animals and explain basic concepts for gene expression and how disturbance of gene expression can increase the risk of disease,

- describe the clinical significance of epigenetic signatures and methods for their analysis,

- account for the significance of different genetic factors for the onset of hereditary diseases and the genetic variation of normal traits,

- account for mitochondrial inheritance and describe related diseases,

- describe genetic and epigenetic factors in the development of cancer,

- account for methods for molecular genetic diagnostics and its implementation,

- describe cloning, transgenic animals, genetic modification and gene therapy,

- discuss ethical aspects of genetics, molecular genetics and genetic modification,

- search and summarize scientific articles on veterinary genetics, molecular genetics and clinical genomics.

Content

The course deals with gene structure, chromatin structure, regulation of gene expression, different types of mutations and chromosome changes, damage to the DNA sequence and its repair. Methods for identifying genetic and epigenetic risk factors and diagnosing them, including clinical sequencing are included. The course aims to give an overview of various current molecular medical techniques and give examples of interpretations of results from these. The course also deals with cloning, transgenic animals and techniques for genetic modification, e.g. CRISPR / Cas9.



An introduction to bioinformatics is given during the course and associated exercises show how information about genes, genome and epigenome can be obtained from different databases. Implementation of diagnostic tests in breeding programs will also be addressed as well as ethical aspects related to clinical diagnostics.



The teaching takes place in the form of lectures, computer exercises, group discussions and laboratory work. Computer exercises and laboratory work are mandatory.

Formats and requirements for examination

Passed written examination and written and oral presentation of the laboratory part. Participation in mandatory parts.
  • If the student fails a test, the examiner may give the student a supplementary assignment, provided this is possible and there is reason to do so.
  • If the student has been granted special educational support because of a disability, the examiner has the right to offer the student an adapted test, or provide an alternative assessment.
  • If changes are made to this course syllabus, or if the course is closed, SLU shall decide on transitional rules for examination of students admitted under this syllabus but who have not yet passed the course.
  • For the examination of a degree project (independent project), the examiner may also allow the student to add supplemental information after the deadline. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Other information

  • The right to take part in teaching and/or supervision only applies to the course date to which the student has been admitted and registered on.
  • If there are special reasons, the student may take part in course components that require compulsory attendance at a later date. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Additional information

Teachin within the course is given online in combination with compulsory physical meetings. The requirement of 4.5 credits genetics can be fulfilled by passed courses

- Biomedicinsk baskurs och Populationsmedicin, eller

- Avel 1, eller

- Avel 2, eller

- Basic Animal Breeding and Genetics



It is recommended that the student has knowledge about basic genetic mechanisms (structure of the genome, replication, transcription), RNA-processing, translation, regulation of gene expression, and basic epigenetic mechanisms, basic genetics and population genetics.

Responsible department

Department of Animal Breeding and Genetics

Further information

Determined by: Programnämnden för utbildning inom veterinärmedicin och husdjur (PN - VH)
Replaces: VM0116

Grading criteria

VM0130 Clinical genomics in veterinary medicine, 7.5 Credits

The aim of the course is to give knowledge about the composition and function of the genomes of domestic animals, as well as the role of genetic and epigenetic factors in development of disease, malformations and developmental disorders.

On completion of the course the student should be able to:
- describe the structure and function of genomes of domestic animals and explain basic concepts for gene expression and how disturbance of gene expression can increase the risk of disease,
- describe the clinical significance of epigenetic signatures and methods for their analysis,
- account for the significance of different genetic factors for the onset of hereditary diseases and the genetic variation of normal traits,
- account for mitochondrial inheritance and describe related diseases,
- describe genetic and epigenetic factors in the development of cancer,
- account for methods for molecular genetic diagnostics and its implementation,
- describe cloning, transgenic animals, genetic modification and gene therapy,
- discuss ethical aspects of genetics, molecular genetics and genetic modification,
- search and summarize scientific articles on veterinary genetics, molecular genetics and clinical genomics.

Grading criteria

Grade

The student shoould:

5

  • in detail evaluate, describe and discuss the functional consequences of genetic variants associated with disease.
  • at a deep level be able to in detail compare and discuss different genetic causes of disease.
  • evaluate and describe in detail the principles of population genetics.
  • in detail describe the organization of genes in the mammalian genome.
  • synthesizes the principles of genome organization, transcription factor function and regulatory sequences to explain the principles of gene expression
  • explains in detail the principles of interaction between oncogenes and tumor suppressor genes in the development of cancer
  • in detail evaluate, describe, compare and discuss analyses the applications of genomic and molecular methods

4

  • show a high level of understanding of the functional consequences of genetic variants associated with disease.
  • show a high level of understanding of the principles of Mendelian inheritance, genetic variation and genetic mapping
  • show a high level of understanding of the organization of genes in the mammalian genome.
  • show a high level of understanding of regulatory mechanisms of biological systems
  • show a high level of understanding of the molecular methods used for genomic analysis

3

  • describes fundamental genetics and molecular genetic terminology
  • describes the basic organization of genes and genomes
  • describe the genetic causes of inherited diseases
  • describes the principles of the development of cancer
  • describes the fundamentals of Mendelian inheritance, genetic variation and genetic mapping
  • describe methods used for genetic testing and molecular genetic research.
  • write and present a mini-review of an inherited disease.
  • complete computational exercises
  • discuss ethical aspects of genetics, molecular genetics and genetic modification

U

Litterature list

  1. Genetics: Analysis of Genes and Genomes (9th edition) Författare: Daniel L. Hartl ISBN: 9781284122930 [Genetics: Analysis of Genes and Genomes (9th edition)] (https://www.jblearning.com/catalog/productdetails/9781284122930)

Course facts

The course is offered as an independent course: Yes Tuition fee: Tuition fee only for non-EU/EEA/Switzerland citizens: 24394 SEK Cycle: Bachelor’s level
Subject: Veterinary Medicine
Course code: VM0130 Application code: SLU-30268 Location: Uppsala Distance course: Yes Language: English Responsible department: Department of Animal Breeding and Genetics Pace: 50%