Uncovering genes with a negative effect on canine health: A next generation sequencing and Bioinformatics framework for dogs
Last changed: 12 March 2018
The overall objective of the proposed project is to identify genetic risk factors for inherited diseases that negatively affect canine health.
The overall objective of the proposed project is to identify genetic risk factors for inherited diseases that negatively affect canine health. This will be done by developing a general framework for whole genome sequencing using next generation sequencing (NGS) technologies followed by bioinformatics evaluation and validation of causative mutations. As a proof-of- concept to uncover genetic risk factors we have selected two inherited canine diseases, pigmentary chorioretinopathy and digital hyperkeratosis. A similar approach will be used to contribute to an increased understanding of complex disease. The results will be evaluated in terms of breeding advice, development of genetic tests as tools for clinical diagnoses and individualized treatments to improve canine health and welfare.
The project is funded by: FORMAS, project nr: 14-1546-28742-59
Duration of the project: 2015-01-01 to 2017-12-31. Disposition time to. 2018-12-31
Project Leader: Göran Andersson
Other contributors: Tomas Bergström, Björn Ekesten, Kerstin Bergvall, Erik Bongcam Rudloff, Marcin Kierczak and Kristina Narfström
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Sayyab S, Viluma A, Bergvall K, Brunberg E, Jagannathan V, Leeb T, Andersson G, Bergström TF. (2016). Whole-genome sequencing of a canine family trio reveals a FAM83G variant associated with hereditary footpad hyperkeratosis. G3: Genes, Genomes and Genetics, 6: 521-527. doi: 10.1534/g3.115.025643.
Viluma A, Sayyab S, Mikko S, Andersson G, Bergström TF. (2015). Evaluation of Whole-Genome Sequencing of Four Chinese Crested Dogs for Variant Detection Using the Ion Proton System. Canine Genetics and Epidemiology (2015) 2:16