Instruments and equipment

NMR and MS- laboratory

NMR-laboratory

The Department of Molecular Sciences has two NMR spectrometers, both installed in 2012:

1. A Bruker Avance III 600 MHz equipped with a 5-mm ¹H/¹³C/¹⁵N/³¹P Cryoprobe and with a cooled SampleJet sample changer for 5x96 samples and 30 spinner positions.
2. A Bruker Avance III 600 MHz equipped with a 4-mm ¹H/¹³C high-resolution magic angle spinning (HR-MAS) probe, a 5-mm BB/¹⁹F-¹H Smartprobe and a sample changer accommodating 120 spinners

The instruments, within the Organic Chemistry and Natural Product Chemistry group, are used for example in metabolomics research, for structural analysis of biomolecules such as polysaccharides, peptides or secondary metabolites. Metabolomics studies involve analysis of biofluids or extracts by high-resolution solution state NMR as well as analysis of intact tissues by HR-MAS NMR.

MS-laboratory

The department of Molecular Sciences has three mass spectrometers, two of them installed end of 2011:

1. A Bruker MaXis Impact ESI-QTOFMS
2. A Bruker AmaZon speed ETD ESI-ITMS
3. A Bruker Reflex III MALDI-TOFMS

The instruments are used for research in the field of proteomics, organic chemistry and natural products chemistry. The QTOF instrument coupled to HPLC is also used in the field of metabolomics due to the high sensitivity and the excellent resolution and mass accuracy of the system.