The organic chemistry group
We perform research within "Metabolomics" and "Biomolecules structure and interactions". We host the NMR and MS platforms at SLU-Uppsala and are providing expertise to many projects. Our NMR platform is the metabolomics node of the national NMR research infrastructure SwedNMR involving 10 universities and supported by the national research council VR-RFI.
Group members
Head of unit:
Corine Sandström, Professor
Researchers
Tatiana Agback, Researcher
Anders Broberg, Professor (web page)
Jan Eriksson, Senior researcher
Ali Moazzami, Senior researcher
Jolanta Levenfors , Researcher
Anders Sandström, Senior lecturer
Research engineers:
Peter Agback, NMR
Suresh Gohil, Mass spectrometry
Post Docs:
Hanna Eriksson Röhnisch
Tahereh Jafari
PhD students:
Elin Alexandersson
Yan Xue
Services
Alumni
Rolf Andersson
Dr. Christina Nord
Dr. Johnny Östman
Dr. Lena Lundqvist
Dr. Frida Wende
Dr. Gustav Nestor
Dr. Eric Morssing Vilen
Dr. Pierre Anderson
Dr. David Hansson
Dr. Johan Bankefors
Dr. Somer Berigoklu
Dr. Birgit Hakkarainen
Dr. Lill Kindahl
Dr. Lars Nord
Dr. Nils Nyberg
Selected publications
H.E. Rohnisch, J. Eriksson, LV Tran, E. Mullner, C. Sandström, AA Moazzami. Improved automated quantification algorithm (AQuA) and its application to NMR-based metabolomics of EDTA-containing plasma. Analytical Chemistry, 93, 8729-8738. DOI: 10.1021/acs.analchem.0c04233 (2021).
Bjerketorp J., Levenfors J.J., Nord C., Guss B., Öberg B., Broberg A. Selective isolation of multidrug-resistant Pedobacter spp., producers of novel antibacterial peptides. Frontiers in Microbiology, 12, 642829. doi: 10.3389/fmicb.2021.642829 (2021)
Mullner, E; Rohnisch, HE ; von Bromssen, C; Moazzami, AA. Metabolomics analysis reveals altered metabolites in lean compared with obese adolescents and additional metabolic shifts associated with hyperinsulinaemia and insulin resistance in obese adolescents: a cross-sectional study. METABOLOMICS, 17 (1), DOI: 10.1007/s11306-020-01759-y (2021)
E Alexandersson, C Sandström, LCE Lundqvist, G Nestor , Band-selective NMR experiments for suppression of unwanted signals in complex mixtures.. RSC Advances, 10, 32511-32515, DOI: 10.1039/d0ra06828d, (2020).
Nord, C., Bjerketorp, J., Levenfors, J.J., Cao, S., Strömstedt, A.A., Guss, B., Larsson, R., Hughes, D., Öberg, B., Broberg. A 2020. Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria. ACS Chemical Biology, 15, 2937-2944. https://doi.org/10.1021/acschembio.0c00568
Rohnisch, HE; Kyro, C; Olsen, A ; Thysell, E ; Hallmans, G ; Moazzami, AA. Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study, BMC MEDICINE, 18 (1), Article Number: 187. DOI: 10.1186/s12916-020-01655-1 (2020)
Agback T; Dominguez F; Frolov I; Frolova EI; Agback P. H-1, C-13 and N-15 resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution. PLOS ONE, 16(12), e0251834. DOI: 10.1371/journal.pone.0251834 (2021)
Lukash T; Agback T; Dominguez F; Shiliaev N; Meshram C; Frolova EI ; Agback P; Frolov I. Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein. Journal of Virology, 95 (1), e01672-20. DOI: 10.1128/JVI.01672-20 (2021).
Wende FJ; Xue Y; Nestor G; Ohrlund A; Sandström C. Relaxation and diffusion of water protons in BDDE cross-linked hyaluronic acid hydrogels investigated by NMR spectroscopy-Comparison with physicochemical properties, Carbohydrate Polymers, 248 (15), 116768, DOI: 10.1016/j.carbpol.2020.116768 (2020)
Contact:
Corine Sandström
Professor in Organic Chemistry
+46 (0) 18- 67 15 04
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SwedNMR team at SLU