Molecular metabolism

The concentration and pattern of metabolites (metabotype) are determined using high-throughput analytical methods i.e. NMR and mass spectrometry. The department of Chemistry and Biotechnology is equipped with the sate-of-the-art instruments for metabolomics analysis i.e. two 600 MHz NMR and a liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-qTOFMS).

The metabolomics based research at the Department of Chemistry and Biotechnology is performed in a close collaboration with researchers from other field to generate a multidisciplinary research platform. The metabolomics based research includes two major areas i.e. public health and sustainable food production.

These are our ongoing projects in molecular metabolism:

• Development and validation of novel NMR and MS methods for measuring the profile of metabolites.
• Identification and validation of diagnostic and prognostic biomarker of chronic disease i.e. prostate cancer, type II diabetes, and Alzheimer disease.
• Establishing strategies for translating metabotype into point-of-care clinical practice (personalized medicine).
• Identification of metabolic responses of signaling pathway involved in development and progression of chronic diseases.
• Identification of health promoting characteristics of food products.
• Monitoring the toxicity of environmental pollutants in aquaculture.
• Optimization of nutritional properties of feed in aquaculture.
• Developing strategies for the application of metabolomics as a new generation of selection tools for crop improvement.
• Developing strategies to link metabolomics with quality traits in crop plants.