Stress granules are transient membraneless organelles which are formed in eukaryotic cells in response to stress. They are composed of messenger ribonucleoprotein complexes, have core-shell substructure and are essential for regulating the rate of protein translation and signalling under stress, with important implications for cancer and neurodegenerative diseases. Our current efforts are to unravel molecular structure of stress granules and their biochemical role in plant development and fitness.
This research is supported by the Swedish Research Council VR.
Gutierrez-Beltran E, Elander PH, Dalman K, Dayhoff GW 2nd, Moschou PN, Uversky VN, Crespo JL, Bozhkov PV (2021) Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis. EMBO J e105043
Gutierrez-Beltran E, Moschou PN, Smertenko AP and Bozhkov PV (2015) Tudor Staphylococcal Nuclease Links Formation of Stress Granules and Processing Bodies with mRNA Catabolism in Arabidopsis. Plant Cell 27: 926-943.